In the time that Jenrry Mejia has been away from the Mets, Jeurys Familia has established himself as the team's unquestioned closer, so successful in that role that he is a Final Vote candidate for the National League All-Star team. But Mejia's return still looms significant in Tuesday's game against the Giants at AT&T Park, which pits veteran right-handers Bartolo Colon and Matt Cain against one another.