Jeremy Guthrie pitched shutout ball into the sixth, Lorenzo Cain drove in an early run off Tim Hudson and made a pair of nifty catches, and the Kansas City Royals led San Francisco 3-2 after six innings Friday night as they tried to take a 2-1 World Series lead. Cain's RBI groundout three batters in put the Royals ahead, and Kansas City expanded its lead to 3-0 in the sixth when Alex Gordon hit an RBI double off Cain and scored on Eric Hosmer's single off left-hander Javier Lopez.