Tim Hudson has struggled against AL opponents since coming to the National League. He'll try to lead the San Francisco Giants to a sweep of this two-game series with the Houston Astros at Minute Maid Park on Wednesday night. He was 10-2 with a 2.50 ERA in 21 interleague games for the A's. Another interleague loss would tie him with Derek Lowe and Barry Zito for the most all-time. Hudson won his lone start against an AL club this year, though, giving up three runs on two homers over a season-best eight-plus innings in a 5-4 victory against the Los Angeles Angels on May 2.